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KMID : 0895820100200010001
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Journal of Oriental Rehabilitation Medicine
2010 Volume.20 No. 1 p.1 ~ p.12
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Effects of Cool Pharmacopuncture for Static Blood into Hyolhae(Sp10 ) on Neurological Recoverment and BAX, BCL-2 Expression in the Experimental Traumatic Brain Injury Rats
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Cho Joo-Hyun
Choi Jin-Bong
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Abstract
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Objectives : Cool Pharmacopuncture for static blood is a famous pharmacopuncture treatment that treated disease caused by static blood. Hyolhae(Sp10) is also a famous point of acupuncture that treated that. This study was designed to evaluate the effects of Cool Pharmacopuncture for static blood into Hyolhae(Sp10) on BAX and BCL-2 expression in the experimental traumatic brain injury(TBI) rats.
Methods : Male rats were divided into 3 groups. Ⅰ was no treatment after TBI. Ⅱ was treatment with needle-prick acupuncture after TBI. Ⅲ was treatment with Cool Pharmacopuncture for static blood into Hyolhae(Sp10) after TBI. The author carried out neurological motor behavioral test, histological assessment test. Neurological motor behavior tests consist of rotarod test, beam-walking test and postural reflex test. In the histological assessment test, BAX and BCL-2 expression, hematoxylin & eosin staining were experimented.
Results : In neurological motor behavior tests, motor and cognitive function recovery was significantly increased in the Ⅱ, Ⅲ as compared with Ⅰ(p<0.05). Especially Ⅲ was significantly increased as compared with Ⅱ(p<0.05). BAX expression was significantly decresed in order of the Ⅲ, Ⅱ, Ⅰ after 7 and 14days later. BCL-2 expression was investigated in the Ⅲ, Ⅱ as compared with Ⅰ. Especially Most incresed expression was experimented in the Ⅲ.
Conclusions : According to the above results, Cool Pharmacopuncture for static blood can inhibit apoptosis of cells after TBI in rats by contol of BAX and BCL expression.
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KEYWORD
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:Sp10, Cool Pharmacopuncture for static blood, Traumaticbra in injury, BAX and BCL-2 expression, Neurological motorbehavioral test
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